KEGG   Homo sapiens (human): 25759
Entry
25759             CDS       T01001                                 
Symbol
SHC2, SCK, SHCB, SLI
Name
(RefSeq) SHC adaptor protein 2
  KO
K17447  SHC-transforming protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
hsa05034  Alcoholism
hsa05100  Bacterial invasion of epithelial cells
hsa05214  Glioma
hsa05220  Chronic myeloid leukemia
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06526  MAPK signaling
  Element
N01595  Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    25759 (SHC2)
   04014 Ras signaling pathway
    25759 (SHC2)
   04370 VEGF signaling pathway
    25759 (SHC2)
   04072 Phospholipase D signaling pathway
    25759 (SHC2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    25759 (SHC2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    25759 (SHC2)
   04062 Chemokine signaling pathway
    25759 (SHC2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    25759 (SHC2)
   04915 Estrogen signaling pathway
    25759 (SHC2)
   04917 Prolactin signaling pathway
    25759 (SHC2)
   04926 Relaxin signaling pathway
    25759 (SHC2)
   04935 Growth hormone synthesis, secretion and action
    25759 (SHC2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    25759 (SHC2)
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    25759 (SHC2)
   05226 Gastric cancer
    25759 (SHC2)
   05214 Glioma
    25759 (SHC2)
   05220 Chronic myeloid leukemia
    25759 (SHC2)
   05224 Breast cancer
    25759 (SHC2)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    25759 (SHC2)
  09165 Substance dependence
   05034 Alcoholism
    25759 (SHC2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    25759 (SHC2)
   01522 Endocrine resistance
    25759 (SHC2)
SSDB
Motif
Pfam: PID SH2
Other DBs
NCBI-GeneID: 25759
NCBI-ProteinID: NP_036567
OMIM: 605217
HGNC: 29869
Ensembl: ENSG00000129946
UniProt: P98077
Position
19:complement(416589..461033)
AA seq 582 aa
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA
DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA
AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR
EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ
VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL
RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT
QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL
DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE
QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV
VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP
NT seq 1749 nt   +upstreamnt  +downstreamnt
atgacgcagggtccgggcgggcgcgcgcccccggcgccccccgcgccccccgagcccgag
gcgcccaccaccttctgcgcgttgctgccccgaatgccgcagtggaagttcgcggccccg
ggcggcttcctgggccgcggcccggcggcggcgcgggcggctggggcctcggggggcgcg
gacccccaacccgagccggcgggcccggggggcgtcccggcgctggcggccgccgtcctg
ggcgcctgcgagccccgctgcgccgcgccctgtcccctgcccgcgctcagccgctgtcgg
ggcgcggggtcgcgggggtcgcggggcgggcggggggcggcggggtccggggacgccgcc
gccgccgccgagtggatccggaagggcagcttcatccacaaacccgcgcacggctggcta
caccccgacgccagggtcctggggcccggggtctcctacgtcgtgcggtacatgggctgc
atcgaggttctccgctctatgcgctccctggactttaacacgcgcacgcaggtgaccagg
gaagccatcaaccggctccatgaggccgtgcctggcgtccggggatcctggaagaaaaag
gcccccaacaaggccctggcgtccgtcctgggcaagagcaaccttcgctttgccggcatg
agcatctccatccacatctccactgatggcctcagcctctccgtgcctgccacgcgccag
gtcatcgccaaccaccacatgccgtccatctccttcgcgtcaggcggagacacggacatg
acggattacgtggcctacgtcgccaaggaccccatcaaccagagagcctgccacatcctg
gagtgctgtgagggcctggcacagagcatcatcagcaccgtgggccaagctttcgagctg
cgcttcaagcagtacctgcacagcccgcccaaggtggcgctgcccccagaaaggctggca
gggccggaggagtcggcctggggggacgaggaggactctttggagcacaattactacaac
agcatcccggggaaggagccgccgctgggcgggctagtggactccaggctggccctgaca
cagccctgcgccctcacggccctcgaccagggcccatctccttctctaagagatgcctgc
agcctgccatgggacgtggggtccaccggtacagctccaccgggggacggctacgtgcag
gcggacgcccggggccccccggaccacgaggagcacctgtatgtcaacacccagggtctg
gacgcccccgagccggaggacagccccaaaaaggatctgtttgacatgcgaccctttgag
gatgccctgaagttgcatgagtgctcagtggcggcaggcgtgacagcagcccctcttccc
ttggaggaccagtggcccagcccccctacccgccgggcccctgtggcccccacggaggaa
cagctgcgtcaggagccctggtaccacggccggatgagccgccgggcggcagagaggatg
cttcgagctgacggggacttccttgtgcgagacagcgtcaccaaccccgggcagtatgtc
ctcaccggcatgcacgccgggcagcccaagcacctgctgctcgtggaccccgagggcgtg
gtacggacgaaggacgtgctgtttgagagcatcagccacctgatcgaccaccacctgcag
aacgggcagcccatcgtggccgccgagagtgagctgcacctgcgtggcgtggtctcacgg
gagccctga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (22)   
   KEGG PATHWAY (22)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (30)   
   RefSeq(nuc) (8)   
   GenBank (11)   
   EMBL (11)   
Protein domain (2)   
   Pfam (2)   
All databases (90)   

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